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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00010513-protein ID=TCONS_00010513-protein|Name=TCONS_00010513-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1284bp
DVPISLSRNKPVVIEDDISNDFVVKGSCEINFGQFVDTDKQDAQNLEKGT
ILEVCDSDVSQMESDAVLEAKILTRMDTVDENAPEMSSTVEGVSETNISV
VRASLVDKDPVISTPTPETSELNPVQNINEDSTPTEATIIETNIIQNAED
DVKVTSETPNIDNNADQSSIENPSPRSKVNFNLTPSISVSRDEDEEEMLP
SIGQNMAITTPETQTSSNGNTTEIQSEDSPKLAPPSPKKKSPGKKRLHSK
NEDILNNYDIIDRTEAKKLQKESNAFSFANVFGRFKKAFGVIEEHPPPRQ
HLTDSGRHRQFQSSTVVNLSVEQTKSGEAMQVITIAPRKDKPHQHQSEGD
DNTDGKMVVYVDELDDDYLEIDQADGGESDAESDGSSIFGDDDVAGDGES
VDVGEDIVGTLHADQNISPATTKGELDHTDALFKTNSMYSLVDDDSKKPA
APVTGVSLKTSQTFSTDRDLRKPSDKDRRPTFGGMGFKSFTLPLSDFGSS
RKSNSPSEPFVLLTDGYPTHLPSFPSDRRSLIALELYTTERTFVRGLEII
VLLFKRKISMNNILDAKDIKSIFANIDEILEINRDILEEIFERISDWSDE
QCIGDIFINHENEFKTYSEYCKNYDTSEALIKQKLKKRKDLETLLTACYS
NPICVPGLTLPSYLITVIQRIPRYILLLKDLIKKTNNDHPDYSNLVKAQE
MMEKSAKYINEQLKQAQCAKALEALQTQITGLKAYYTPDRTLVHEGDVCL
MTSKKTYHCVLFNDLLVFAVKSGVRQMSVELALEIKNVWIEDLHELDPQT
TKKDAIGIYTPERPYTMYVGGIGEKKIWLKNLRETIRSNLYGQNDKENTE
TDIRKTNFTYKDETVYSGFYCKAKRQGQGTGMWPNLFTYIGEWEDDERNG
YGVLNYACGDNYEGQWLDNKQDGEGVYTNKRGDKVTGTWKDGIKNGDVII
EYHNGDSFHGFCMDDKIVGEGELVCKNGYRYKGQWKDNLQHGNGHLITPD
GYEYTGAFKFNKFHGTGELLYPDGSIYKGEFDRGERSGQGTYTQPGGVSY
EGQWMHDLKDGRGKMEYENGDVYEGTWMQDMRIGQGVMVYSYGGFYRGQW
QSDLMHGSGVLELKDGSTYDGEFHYNKMCGSGKMKYKNGAMYNGEWQDNC
QCGKGILTKPGQWSCDGHWQQGKQHGLCLLNDPVNNYSYEGQWVNGVKEG
KGKEKLKDSTFEGTFVEDMRQGSGEEKFKDGSIYKGTWLRGQKNGAFTLR
RQHTIEHQIWNYGCLVRAPTDLPPRDIPLLQRWL Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Biological Process
| Term | Definition |
|---|
| GO:0035023 | regulation of Rho protein signal transduction |
Vocabulary: Molecular Function
| Term | Definition |
|---|
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
| Category |
Term Accession |
Term Name |
| biological_process |
GO:0035023 |
regulation of Rho protein signal transduction |
| molecular_function |
GO:0005089 |
Rho guanyl-nucleotide exchange factor activity |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
| IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
|---|
| IPR000219 | Dbl homology (DH) domain | SMART | SM00325 | RhoGEF_3 | coord: 532..711
e-value: 1.8E-58
score: 210.2 |
| IPR000219 | Dbl homology (DH) domain | PFAM | PF00621 | RhoGEF | coord: 533..710
e-value: 1.8E-48
score: 165.1 |
| IPR000219 | Dbl homology (DH) domain | PROSITE | PS50010 | DH_2 | coord: 528..712
score: 33.143 |
| IPR000219 | Dbl homology (DH) domain | SUPERFAMILY | 48065 | DBL homology domain (DH-domain) | coord: 527..732 |
| IPR003409 | MORN motif | SMART | SM00698 | morn | coord: 1117..1138
e-value: 3.2E-4
score: 30.0
coord: 1232..1253
e-value: 35.0
score: 2.5
coord: 1002..1023
e-value: 0.15
score: 20.2
coord: 1071..1092
e-value: 0.22
score: 19.0
coord: 1048..1069
e-value: 0.17
score: 19.9
coord: 1187..1208
e-value: 0.004
score: 26.4
coord: 1094..1115
e-value: 0.0077
score: 25.4
coord: 1025..1046
e-value: 0.012
score: 24.8
coord: 864..885
e-value: 5.5
score: 8.6
coord: 887..908
e-value: 0.37
score: 17.3
coord: 1140..1161
e-value: 0.14
score: 20.5
coord: 910..931
e-value: 3.9E-4
score: 29.7
coord: 1209..1230
e-value: 0.63
score: 15.6
coord: 979..1000
e-value: 0.0015
score: 27.8 |
| IPR003409 | MORN motif | PFAM | PF02493 | MORN | coord: 1073..1091
e-value: 0.79
score: 9.6
coord: 1027..1047
e-value: 0.0066
score: 16.2
coord: 889..907
e-value: 0.0023
score: 17.6
coord: 912..933
e-value: 9.6E-4
score: 18.8
coord: 1165..1178
e-value: 1.4
score: 8.9
coord: 1211..1232
e-value: 0.011
score: 15.4
coord: 1050..1072
e-value: 5.7E-5
score: 22.7
coord: 1234..1245
e-value: 8.7
score: 6.4
coord: 1004..1025
e-value: 0.0032
score: 17.2
coord: 1189..1208
e-value: 2.1E-4
score: 20.9
coord: 1119..1140
e-value: 1.8E-4
score: 21.1
coord: 1142..1160
e-value: 4.1
score: 7.4
coord: 1096..1118
e-value: 9.7E-5
score: 21.9
coord: 981..1001
e-value: 7.8E-5
score: 22.2 |
| IPR001849 | Pleckstrin homology domain | SMART | SM00233 | PH_update | coord: 742..839
e-value: 5.9E-4
score: 29.1 |
| IPR011993 | PH domain-like | GENE3D | 2.30.29.30 | | coord: 721..846
e-value: 1.4E-13
score: 50.1 |
| IPR011993 | PH domain-like | SUPERFAMILY | 50729 | PH domain-like | coord: 720..837 |
| None | No IPR available | GENE3D | 2.20.110.10 | | coord: 1190..1270
e-value: 1.1E-12
score: 47.9
coord: 943..1009
e-value: 2.6E-15
score: 56.4
coord: 1124..1189
e-value: 1.1E-12
score: 47.9
coord: 1065..1123
e-value: 3.1E-20
score: 72.3
coord: 867..942
e-value: 2.8E-17
score: 62.7
coord: 1010..1064
e-value: 4.8E-20
score: 71.7 |
| None | No IPR available | GENE3D | 1.20.900.10 | | coord: 525..720
e-value: 1.8E-59
score: 200.3 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 374..397 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 110..134 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 156..251 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 462..484 |
| None | No IPR available | CDD | cd00160 | RhoGEF | coord: 529..710
e-value: 1.05328E-52
score: 183.268 |
| None | No IPR available | SUPERFAMILY | 82185 | Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | coord: 977..1095 |
| None | No IPR available | SUPERFAMILY | 82185 | Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | coord: 1092..1208 |
| None | No IPR available | SUPERFAMILY | 82185 | Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain | coord: 861..988 |
Blast
BLAST of TCONS_00010513-protein vs. Swiss-Prot (Human)
Match: ALS2 (Alsin OS=Homo sapiens GN=ALS2 PE=1 SV=2) HSP 1 Score: 130.568 bits (327), Expect = 2.484e-30 Identity = 118/418 (28.23%), Postives = 182/418 (43.54%), Query Frame = 0
Query: 668 IQRIPRYILLLKDLIKKTNNDHPDYSNLVKAQEMMEKSAKYINEQLKQAQCAKAL-EALQTQITGLKAYYTPDRTLVHEGDVCLMTSKKTYHC-----VLFNDLLVFAVKSGVRQMSVELALEIKNVWIEDLHELDPQTTKKDAIGIYTPERPYTMYVGGIGEKKIWLKNLRETIRSNLYGQND---------KENTETDI-RKTNFT-YKD----ETVYSGFYCKAKRQGQGTGMWPNLFTYIGEWEDDERNGYG---VLNYACG--DNYEGQWLDNKQDGEGVYTNKRGDKVTGTWKDGIKNGDVIIEYHNGDS-----FHGFCMDDKIVGEGELV-CKNGYRYKGQWKDNLQHGNGHLITPDGYEYTGAFKFNKFHGTGELLYPDGSIYKGEF-DRGERSGQGTYTQPGGVSYEG 1052
I+R+ Y +L L P+Y L + E A ++ + K+A+ + ++T + P+R L+ E ++ + +LFND LV A Q S + +W E L E + + + I TPE +T+ EK WL+ + + + L G +D + E I R +T YKD + Y G + K G+G WP+ Y G + + +GYG + N A D+Y G W + K G+GVY+ G+ G ++D +++G ++ S F G + DK G G G +Y G W+D++ GNG ++T G Y G F NK G G LL D +IY+GEF D SG+GT T P G EG
Sbjct: 841 IRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFPGKMT--DSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHA------QFSTHHVFPLATLWAEPLSE---EAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSGSSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEG 1247 HSP 2 Score: 108.997 bits (271), Expect = 9.768e-24 Identity = 71/230 (30.87%), Postives = 109/230 (47.39%), Query Frame = 0
Query: 981 YKGQWKDNLQHGNGHLITPDGYEYTGAFKFNKFHGTGELLYPDGSI-----YKGEFDRGERSGQGTYTQPGGVSYEGQWMHDLKDGRG-----KMEYENGDVYEGTWMQDMRIGQGVMV-YSYGGFYRGQWQSDLMHGSGVLELKDGSTYDGEFHYNKMCGSGKMKYKNGAMYNGEWQDNCQC-GKGILTKPGQWSCDGHWQQGKQHGLCLLNDPVNNYSYEGQWVNGVK 1198
Y G+W HG G L PDG Y+G F+ G GE P+ ++ Y G + G+ GQG Y+ G +EG + +++ G G K+ + ++ G W+ D + G GV + G Y G WQ D+ G+GV+ + G Y+G FH NKM G+G + ++ +Y GE+ D+ GKG LT P D + Y + G+W +G+K
Sbjct: 1049 YDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPN-------------------GDYIEGY-FSGEWGSGIK 1258
The following BLAST results are available for this feature:
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