TCONS_00011235-protein (polypeptide) - C. hemisphaerica

Overview
NameTCONS_00011235-protein
Unique NameTCONS_00011235-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length1582

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00011235-protein ID=TCONS_00011235-protein|Name=TCONS_00011235-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1582bp
MDREEPQDEEKEPSAPPRRKSIKGKPVKRSIALIAEKDDTSIEIKEEENT
RPKTPLRPPKPSLPDKPVEPTRPENQENSAEIVYKKDVLIDSKKAPLKPP
PPKQKSDLSKSPSQKRAPIKPPPPTKSIPQIDNNKETISKTKGSITSDST
LEKPTTPEPEHKKAPRKPPQPNKLSHEDSVLQSKQDTTESNKEKIIDEKQ
PELSQSHKVKKAPQKPPPPKQDQREPLQDKGSELSNESEETEISDSPKLE
EKEVNEKKGAEPKTIPKKPPPPSQADKDLSKRTNSVSKKGPEKPRPPRII
KERPPSPQLSEGKSTPQKPPPPKSPLKKTESTPEPSVTKKERPPIPKSPS
LKARKPIAENQTMFEEQNTLSPPKARPRPVPRPRKNDDKPAVTPVPTPRR
KESENNDNKEQSSNKKMEESSTIKDNSTKENDVTKTDNEVSTVETSTLDP
DTTVSIDTSSTVDTDSKTTDETTDISSTIDTDKAPSREPKTSDSPNKTSG
VKQKSRTPAPYENIEVQSPAKSPKKNVYVNVEVDGEQALIKEETGGDQIY
DSPTSPSSKMSKTLQNSITKETITSNDVNLVEESLYDAPASSATKTLSST
TFDSSVKTLSYDQQQSLMEQEALYDAPPRSPTKRTNMNRSDSQDSIDEST
GEGIYDAPQSPIKSYGNTIKPPGNTIDPHVNMTSPHRNTPKSNAPSPPLQ
EQPQEENIYAAPTNPVTVDSQDAGFDKDRVIDLQSKKKYRAPLPPSSPTA
TLSNIAQRPTPMNPNAPVVSYSMMRSEEEQAGDGEEETIYSNIEGQEEEE
SLYSAPLSTPVKKPPTPPWSDKSRTLSDLSLATSSGSARSSMASSRSSRG
SSVMAYEDIPEYKVPGMKTEAGLDSTASTPSSFRDSKYVDMTMSSPPPPT
KPPRPGSMTKRPDSGYETVAPPPQSPSRAEIQKRSLPPRPPVPKSALQQQ
QQQQQQPQIDDEKENIAVETMSHETALDSNFYQSVDSLRREGLQSEELSS
DSDSESEDENTSNVAEDSKGFENKSKLFYIAYEILTTEKTFVEALALICD
DFGVPLKGALEKNSRLLPENGYTLMFLNIESIYELDKKFLHDLEERMENW
EMFKKIGDLVRGYCHFLKMYTTYIKGYDNAMAMYHDQINNNMKFSQLVKE
FEKSKKAKNLKLTTYLLKPIQRIPSYRLLLKEYLKHLPDDNVDYNDIKES
VAIVSDVANHINESMKEGEKFQEVLRIQSQIENRNDIIKPGRFLIKEGML
LKLSRKELQQRTFILFTDSLLYCAHLGHGQLKLILELPLAGMLVQFPDSQ
ELSIEFSVISTKRSFLLNASSPKEREDWVAALQEAINVSNKKIGTFTVNR
NSDESGSFQSSISSDIGVIAPPWIPDSRVTMCQVCTTQFNVYNRRHHCRG
CGKVVCKTCSSFEAPLTYMRNESARVCEKCYDVLLENIKSLDEETKGVLT
AKFKNGKAKKKSKKRVENLPSTLTEINAQQEGIANSGFLRLKRGTKKEKR
CWFVLKEHVLYLYKAASDPAAHTTIPVLGYQLDITGNWDEEDFGFQLSHA
GVKESLVFHADNRSSAERWVHCFCKATALETT
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_006287XLOC_006287Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00011235TCONS_00011235Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR000306Znf_FYVE
IPR000219DH-domain
IPR001849PH_domain
IPR011993PH_dom-like
IPR013083Znf_RING/FYVE/PHD
IPR017455Znf_FYVE-rel
IPR011011Znf_FYVE_PHD
Vocabulary: Molecular Function
TermDefinition
GO:0046872metal ion binding
GO:0005089Rho guanyl-nucleotide exchange factor activity
Vocabulary: Biological Process
TermDefinition
GO:0035023regulation of Rho protein signal transduction
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0035023 regulation of Rho protein signal transduction
molecular_function GO:0046872 metal ion binding
molecular_function GO:0005089 Rho guanyl-nucleotide exchange factor activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000306FYVE zinc fingerSMARTSM00064fyve_4coord: 1368..1436
e-value: 9.5E-29
score: 111.5
IPR000306FYVE zinc fingerPFAMPF01363FYVEcoord: 1372..1434
e-value: 2.4E-19
score: 69.1
IPR000219Dbl homology (DH) domainSMARTSM00325RhoGEF_3coord: 1030..1213
e-value: 5.7E-53
score: 192.0
IPR000219Dbl homology (DH) domainPFAMPF00621RhoGEFcoord: 1030..1212
e-value: 4.9E-43
score: 147.4
IPR000219Dbl homology (DH) domainPROSITEPS50010DH_2coord: 1026..1214
score: 33.368
IPR000219Dbl homology (DH) domainSUPERFAMILY48065DBL homology domain (DH-domain)coord: 1021..1235
IPR001849Pleckstrin homology domainSMARTSM00233PH_updatecoord: 1483..1580
e-value: 1.2E-12
score: 58.0
coord: 1244..1339
e-value: 2.4E-15
score: 67.0
IPR001849Pleckstrin homology domainPFAMPF00169PHcoord: 1245..1336
e-value: 1.0E-8
score: 35.5
coord: 1486..1577
e-value: 4.7E-11
score: 43.0
IPR001849Pleckstrin homology domainPROSITEPS50003PH_DOMAINcoord: 1243..1337
score: 12.394
IPR001849Pleckstrin homology domainPROSITEPS50003PH_DOMAINcoord: 1482..1578
score: 11.508
NoneNo IPR availableGENE3D1.20.900.10coord: 995..1226
e-value: 1.1E-52
score: 178.2
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 988..1017
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 539..566
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..525
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 588..961
NoneNo IPR availableCDDcd00160RhoGEFcoord: 1029..1212
e-value: 9.06931E-46
score: 164.008
IPR011993PH domain-likeGENE3D2.30.29.30coord: 1437..1581
e-value: 1.4E-15
score: 56.8
IPR011993PH domain-likeGENE3D2.30.29.30coord: 1227..1365
e-value: 1.0E-26
score: 92.6
IPR011993PH domain-likeSUPERFAMILY50729PH domain-likecoord: 1394..1577
IPR011993PH domain-likeSUPERFAMILY50729PH domain-likecoord: 1219..1336
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3D3.30.40.10coord: 1366..1436
e-value: 2.3E-21
score: 74.9
IPR017455Zinc finger, FYVE-relatedPROSITEPS50178ZF_FYVEcoord: 1376..1435
score: 12.719
IPR011011Zinc finger, FYVE/PHD-typeSUPERFAMILY57903FYVE/PHD zinc fingercoord: 1371..1444

Blast
[Close]
BLAST of TCONS_00011235-protein vs. Swiss-Prot (Human)
Match: FGD6 (FYVE, RhoGEF and PH domain-containing protein 6 OS=Homo sapiens GN=FGD6 PE=1 SV=2)

HSP 1 Score: 426.017 bits (1094), Expect = 6.737e-125
Identity = 230/575 (40.00%), Postives = 345/575 (60.00%), Query Frame = 0 
Query: 1024 KSKLFYIAYEILTTEKTFVEALALICDDFGVPLKGALEKNSRLLPENGYTLMFLN-----IESIYELDKKFLHDLEERMENWEMFKKIGDLVRGYCHFLKMYTTYIKGYDNAMAMYHDQINNNMKFSQLVKEFEKSKKAKNLKLTTYLLKPIQRIPSYRLLLKEYLKHLPDDNVDYNDIKESVAIVSDVANHINESMKEGEKFQEVLRIQSQIENRNDIIKPGRFLIKEGMLLKLSRKELQQRTFILFTDSLLYCAHLGHGQLKLILELPLAGMLVQFPDSQELSIEFSVISTKRSFLLNASSPKEREDWVAALQEAINVSNKKIGTFTVNRNSDESGSFQSSISSDIGVIAPPWIPDSRVTMCQVCTTQFNVYNRRHHCRGCGKVVCKTCSSFEAPLTYMRNESARVCEKCYDVLLENIKSLDEET-------------KGVLTAKFKNGKAKKKSKKRVENLPSTLTEINAQQEGIANSGFLRLKRGTKK-EKRCWFVLKEHVLYLYKAASDPAAHTTIPVLGYQLDITGNWDEEDFGFQLSHAGVKESLVFHADNRSSAERWVHCFCKATAL 1579
            KSK+ +IA EI+++EK FV+ L L+  DF    + A+   SR L +       LN     +  +YEL++  L +LEERM +W   ++I D+      +LKMY+TYIK +D  +A+  +Q   N  F+ +V+EFE S +  NL L  YLLKP+QRIP YRLLL +YLK+L +D  DY D ++++A+V +VANH N++MK+G+ FQ++++IQ  +   ++I++PGR  +KEG+L+KLSRK +Q R F LF D+LLY   +  G  KL   L LAGM V+ P  +    E  + S +RSF+L+ASS  ER++W+ A+  AI    KK  TF  +R+ DE+ S      S +G  AP WIPD+R TMC +CT++F +  RRHHCR CGK+VC+ CSS +  L Y++N+ ARVCE C+    + ++ LD +                 L++   +  + +K KK    +P+ L E++A  E  + SG+L   +G KK  K  WFV+K  VLY Y A+ D AA  + P+LG+ +    + + E   FQL H  +    VF A++  SA++W+  F + T L
Sbjct:  869 KSKVHHIAKEIMSSEKVFVDVLKLLHIDF----RDAVAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARVCEHCF----QELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKK----IPAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLLGFTVIQVKDENSESKVFQLLHKNML-FYVFKAEDAHSAQKWIEAFQEGTIL 1430
The following BLAST results are available for this feature:
BLAST of TCONS_00011235-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
FGD66.737e-12540.00FYVE, RhoGEF and PH domain-containing protein 6 OS... [more]
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