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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00027721-protein ID=TCONS_00027721-protein|Name=TCONS_00027721-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1658bp
MTTLMMNMSIELKKYFLFFWWSTLCCCWLPFLSCIQALSQEGMTIEQDSY
GVDLNTLKHYEIVYPIELESTQAYTKHYQISAFGQSYDIFIKQNDILDRR
EVNGTTQDNLNNNIYVEYIDRNNSYQGKYWKPNNCFYNGPSVNDESLYLV
LDYCDGLEGMIEDQNTTLFIEPIKTQNDTTTSSTTTTSNPYRKHLVYRSS
DVKHKSKLIVDRTEKEPAIDFRLHALSSRRRQRRSGYQSFLYVINRSNRK
VQIYYYDLKDRLIPFILLLPNEGRGINTFEATKWVVKDDRSDQIFHLNGR
SDYTSTVNSQDKRYELVITVPPGTVFNDATSETNEVGGADYYIEVMILAD
KSMVDYHKKTHIEKYLNTMNQIVAGIFKHKSLGSRIHYKVTKIVLLESND
IGFSVYKGNPSRTLRSACEYTTSLKHSDEKHPDHFDVAIAITRKQFGPSG
YAQMYSMCSNRRSCAIVNDEGLTSSFIVAHEVAHLLGLDHDGEGDSSRCK
DDQSRGSVMAPVIVSSYSRYHWSSCSREVLKVNIGYFSCLENNPNKQKEQ
VSNKLPGSSYTIDEQCRMSHQGSSKCTTFDFNPCHRLWCSSTERKCISRG
PALSGTVCGKNKFCFKGECVEEEDNQTTKLTTKRIVHGQWSRWTSWSSCS
QSCGVGLRFRSRDCDSPRPGPRGRDCSGQRKEMDICSTQPCRLMKSYQTI
LDEQCSSIRDERWIRYKDQDFETRLKAPRNNLNCTFEDGMCNWQKEAIRS
DLEWNLQSGPTNSRQTGPSSDHTTGTKSGKYIYMEASSTYLSRKHEGDVA
RLVSRVVQVPRVCFTFYYHMYGRDMGSLRVNVRFKNGTEVNRWNITGNQG
DRWQSARISVENPEDFQFIIEAVRGGHWSGDIAVDDFSIAVGSCPEVRDP
NPCKVSCRSRSALSFTLNLNVHDGVNCNPDPRSNDICLKGICVPFGCDNQ
FGSTSKLDNCGVCGGNGSSCSLRKGTKRVQLKQSYEVLFKLKKGSTFIEF
VEKSDQFLYYGIRKKSNNAIHLSTSQEDYFIIGDVTFHFYKVNGRQRISS
KGPTKEDLEIMVFSYQRSRVKPVVIDYDYYEPKGFTYEYRVTSWEPCSMS
CGIGKQKSLSRCVRTDDNRKVSDAFCEGVKKPTVNYRTCKMKPCPERYIW
MPRQWRECDKSCGGGRQYRKIDCVRVQDSALVSHRYCKSGDKPEESKICN
TNKCYRWKAREWSSCSVSCGKGVRIRLTTCMDGDLAVEPEKCREEDRPRD
HEVCQLQECEKFRWRVMYESACSKSCGGGNKAIIVNCVKVRKPNVPVDNE
FCTGPEPARLKRCNTQACPEYVWKFGEEGPCSATCGSGTRERSVICVDQA
TDVETNEKNCKEKKPDIVVPCNERLCMRYKVAYSAWQDCDVMCGLGVQKR
NPYCITEDYKRVVDHSLCGKQAKVKEERVCQKSSCAKPADLQCSFTKKST
CKWENGQTDDFDWSIGKNTPSLNTGPNSDHTTTNGYFAFIEASRPRRSGD
RATLVSPIVRAKNGCLTFWYHMRGSTVGHLRLYLSTSVASNVLFEQKGEK
GRKWLLATIDVSPSSGTLSGYKFIFEGKVGRAAYGDIAIDDINFYDQSCK
DLKVFHNPILENCRERSPLCKKKDIVERYCRESQQFQLLCCKTCVKFMKK
NSYTLTHS Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Cellular Component
| Term | Definition |
|---|
| GO:0016020 | membrane |
Vocabulary: Molecular Function
| Term | Definition |
|---|
| GO:0008237 | metallopeptidase activity |
| GO:0004222 | metalloendopeptidase activity |
Vocabulary: Biological Process
| Term | Definition |
|---|
| GO:0006508 | proteolysis |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
| Category |
Term Accession |
Term Name |
| biological_process |
GO:0006508 |
proteolysis |
| cellular_component |
GO:0016020 |
membrane |
| molecular_function |
GO:0004222 |
metalloendopeptidase activity |
| molecular_function |
GO:0008237 |
metallopeptidase activity |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
| IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
|---|
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | SMART | SM00209 | TSP1_2 | coord: 640..692
e-value: 5.3E-11
score: 52.6
coord: 1147..1205
e-value: 0.051
score: 20.8
coord: 1381..1436
e-value: 0.072
score: 19.4
coord: 1206..1260
e-value: 1.3E-5
score: 34.7
coord: 1322..1377
e-value: 5.4E-5
score: 32.6
coord: 1088..1145
e-value: 0.03
score: 22.8
coord: 1264..1319
e-value: 0.29
score: 14.0 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | GENE3D | 2.20.100.10 | | coord: 1320..1376
e-value: 5.0E-9
score: 35.9
coord: 1377..1436
e-value: 1.8E-7
score: 30.9
coord: 1260..1319
e-value: 1.1E-6
score: 28.5
coord: 1204..1259
e-value: 5.2E-11
score: 42.3
coord: 1146..1203
e-value: 6.3E-9
score: 35.6
coord: 1085..1145
e-value: 3.6E-10
score: 39.6 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | PFAM | PF00090 | TSP_1 | coord: 1329..1376
e-value: 1.6E-4
score: 21.7
coord: 641..691
e-value: 7.8E-9
score: 35.5
coord: 1211..1259
e-value: 1.3E-5
score: 25.2
coord: 1092..1144
e-value: 0.066
score: 13.3 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | GENE3D | 2.20.100.10 | | coord: 636..691
e-value: 5.8E-15
score: 54.8 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | PROSITE | PS50092 | TSP1 | coord: 1378..1436
score: 8.138 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | PROSITE | PS50092 | TSP1 | coord: 1203..1260
score: 10.892 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | PROSITE | PS50092 | TSP1 | coord: 1319..1377
score: 10.261 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | PROSITE | PS50092 | TSP1 | coord: 637..692
score: 13.766 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | PROSITE | PS50092 | TSP1 | coord: 1085..1145
score: 8.582 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | SUPERFAMILY | 82895 | TSP-1 type 1 repeat | coord: 1204..1259 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | SUPERFAMILY | 82895 | TSP-1 type 1 repeat | coord: 1270..1318 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | SUPERFAMILY | 82895 | TSP-1 type 1 repeat | coord: 636..691 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | SUPERFAMILY | 82895 | TSP-1 type 1 repeat | coord: 1149..1204 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | SUPERFAMILY | 82895 | TSP-1 type 1 repeat | coord: 1321..1376 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | SUPERFAMILY | 82895 | TSP-1 type 1 repeat | coord: 1089..1144 |
| IPR000884 | Thrombospondin type-1 (TSP1) repeat | SUPERFAMILY | 82895 | TSP-1 type 1 repeat | coord: 1382..1435 |
| IPR000998 | MAM domain | SMART | SM00137 | MAM_2 | coord: 1438..1601
e-value: 2.1E-40
score: 150.2
coord: 729..896
e-value: 5.4E-41
score: 152.2 |
| IPR000998 | MAM domain | PFAM | PF00629 | MAM | coord: 734..895
e-value: 5.2E-40
score: 136.8
coord: 1443..1600
e-value: 1.5E-38
score: 132.1 |
| IPR000998 | MAM domain | PROSITE | PS50060 | MAM_2 | coord: 1441..1601
score: 33.2 |
| IPR000998 | MAM domain | PROSITE | PS50060 | MAM_2 | coord: 732..896
score: 35.723 |
| IPR000998 | MAM domain | CDD | cd06263 | MAM | coord: 734..894
e-value: 1.81481E-46
score: 165.244 |
| IPR000998 | MAM domain | CDD | cd06263 | MAM | coord: 1443..1599
e-value: 1.82515E-42
score: 153.688 |
| None | No IPR available | PFAM | PF13688 | Reprolysin_5 | coord: 343..517
e-value: 1.2E-10
score: 41.8 |
| None | No IPR available | GENE3D | 2.60.120.200 | | coord: 1440..1601
e-value: 4.3E-46
score: 156.4
coord: 731..896
e-value: 7.6E-49
score: 165.3 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 756..778 |
| None | No IPR available | SUPERFAMILY | 55486 | Metalloproteases ("zincins"), catalytic domain | coord: 340..542 |
| IPR024053 | von Hippel-Lindau disease tumour suppressor, beta domain | GENE3D | 2.60.40.780 | | coord: 224..319
e-value: 9.5E-9
score: 35.0 |
| IPR002870 | Peptidase M12B, propeptide | PFAM | PF01562 | Pep_M12B_propep | coord: 73..197
e-value: 4.1E-10
score: 39.9 |
| IPR010294 | ADAM-TS Spacer 1 | PFAM | PF05986 | ADAM_spacer1 | coord: 980..1080
e-value: 2.4E-4
score: 21.0 |
| IPR024079 | Metallopeptidase, catalytic domain | GENE3D | 3.40.390.10 | | coord: 338..564
e-value: 2.1E-57
score: 193.9 |
| IPR001590 | Peptidase M12B, ADAM/reprolysin | PROSITE | PS50215 | ADAM_MEPRO | coord: 341..528
score: 12.267 |
| IPR022772 | von Hippel-Lindau disease tumour suppressor, beta/alpha domain | SUPERFAMILY | 49468 | VHL | coord: 230..322 |
| IPR013320 | Concanavalin A-like lectin/glucanase domain | SUPERFAMILY | 49899 | Concanavalin A-like lectins/glucanases | coord: 731..894 |
| IPR013320 | Concanavalin A-like lectin/glucanase domain | SUPERFAMILY | 49899 | Concanavalin A-like lectins/glucanases | coord: 1438..1599 |
Blast
BLAST of TCONS_00027721-protein vs. Swiss-Prot (Human)
Match: ATS3 (A disintegrin and metalloproteinase with thrombospondin motifs 3 OS=Homo sapiens GN=ADAMTS3 PE=2 SV=4) HSP 1 Score: 293.893 bits (751), Expect = 2.363e-81 Identity = 156/425 (36.71%), Postives = 240/425 (56.47%), Query Frame = 0
Query: 323 GTVFNDATSETNE-------VGGADYYIEVMILADKSMVDYHKKTHIEKYLNTMNQIVAGIFKHKSLGSRIHYKVTKIVLLESNDIGFSVYKGNPSRTLRSACEYTTSLKHSDEKHPDHFDVAIAITRKQFGPSG---YAQMYSMCSNRRSCAIVNDEGLTSSFIVAHEVAHLLGLDHDGEGDSSRCKDDQSRGSVMAPVIVSSYSRYHWSSCSREVLKVNIGYFSCLENNPNKQKEQVSNKLPGSSYTIDEQCRMSHQ-GSSKCTTF-DFNPCHRLWCSSTERKCI---SRGPALSGTVCGKNKFCFKGECVEEEDNQTTKLTTKRIVHGQWSRWTSWSSCSQSCGVGLRFRSRDCDSPRPGPRGRDCSGQRKEMDICSTQPCRLMKSYQTILDEQCSSIRD--------ERWIRYKDQDFETR 724
GTV+ + + NE G DY IEV++ D S+V +H K H++ YL T+ IV I+ +SLG I+ + ++++L + +GNPSR+L + C + + + SD H +H D AI +TR+ FGP+G YA + MC RSC + +++G +S+F+VAHE H+LG++HDG+G+ RC D+ + GSVMAP++ +++ RYHWS CS + LK I + CL ++P +LPG +Y++DEQCR G CT F F+PC +LWCS + +GP L GT C K+C+KG C+ + NQ + G W WT + SCS++CG G+RFR+R C++P P G+DC G E +C+T+ C+ K ++ +QC W+ Y+ D + R
Sbjct: 231 GTVYGNIHQQLNETMRRRRHAGENDYNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGN--RCGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQ-------DGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQ--KHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKR 644 HSP 2 Score: 162.54 bits (410), Expect = 4.972e-40 Identity = 116/389 (29.82%), Postives = 180/389 (46.27%), Query Frame = 0
Query: 900 PNP---CKVSCRSRSA--LSFTLNLNVHDGVNCN-PDPRSNDICLKGICVPFGCDNQFGSTSKLDNCGVCGGNGSSCSLRKGT-KRVQLKQSYEVLFKLKKGSTFIEFVEKSDQFLYYGIRKKSNNAIHLSTSQEDY----FIIGDVTFHFYKVNGRQRISSKGPTKEDLEIMVFSYQ---RSRVK----------PVVIDYDYYEPKGFTYEYRVTSWEPCSMSCGIGKQKSLSRCVRTDDNRKVSDAFCEGVKKPTVNYRTCKMKPCPERYIWMPRQWRECDKSCG-GGRQYRKIDCVRVQDSAL---VSHRYCKSGDKPEESKICNTNKC-YRWKAREWSSCSVSCGKGVRIRLTTCMDGDLAVEPEKCREEDRPRDHEVCQLQEC 1259
P+P C + C+S+ +++ L VHDG +C+ DP S IC++G CV GCD + GS D CGVCGG+ S C KGT R K Y +F + G+ + E I+ ++ L+ E+ FI V + + + + + + GP + + +++ + RS + P + + + + T+E+ + SW CS CG G Q + C R DN+ V +FCE KKP R C ++ C +W+ +W C K+CG G Q R + C++ V +YC GD+PE + CN C +WK WS CSV+CG+G +R C GD + ++P CQL C
Sbjct: 639 PDPKKRCHLYCQSKETGDVAYMKQL-VHDGTHCSYKDPYS--ICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGEEAKSRTFIDLGVEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQEC-THPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCM-GDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAGDHC-------DGEKPESVRACQLPPC 1015
The following BLAST results are available for this feature:
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