TCONS_00007329-protein (polypeptide) - C. hemisphaerica

Overview


Name	TCONS_00007329-protein
Unique Name	TCONS_00007329-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	946

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00007329-protein ID=TCONS_00007329-protein|Name=TCONS_00007329-protein|organism=Clytia hemisphaerica|type=polypeptide|length=946bp
MGVIKGLFCSESAAGKECQNDKFCGEDEICVCNAKCESNRCIKGSREAEK
TNNGNGNGDGKSSNGNGNKYGHFTNLTDVGLNSTNASSDACHPHPCNNGT
CSQAQSNFTCICHDGWEGRLCEIPKCTLKCNHSKAQCNFRSPGKEQFCQC
TIAGMTGASCESDINECNITETICHHGECENTPGSYKCHCDDFYTGPTCN
DREDTCNTKSNKCHQNATCINEINSPEGYKCVCRNGYTGKYCDALVDNCA
AANCGNGQCINKFNDYTCTCHDGYTGKNCETKIKNESCPYDDCDRTQCDK
RCNIPKCNYDAYLCTFNLDPFKQCDIQECKNAINGTCRSDCDNMNCLYDS
GNCIKPKKCSLEEQCKKAYGDGVCHPLCNTVDCGFDIDCISEPNLIPGSL
VLEIDSTEGEFKAKKSQFEFELSRQLNSLVTVKSVRTLNAGFKRKRRSIS
NNTSPRLEVTMKMDNSKCVSQCFSTEQAARFLALKSANDDLRLPVRVVKV
SSKPSGEPPITPSISPLWIALIVVGAVCAIGVIYGAKTVKTRFWKPEETT
GPGKRETPIGQEELQILDESRDSKRQKLGFDHSEPFLNGMTDMNGMNGMH
GLNINNMNNMNIGMIPNDTIDQQQHHDNPLHYAAHHGIIHILRTQMDYVD
VNKRDNTGRTALHVATSTGNDDIFAHLIRNRSINPDIQDDEGETPLMVAV
RMAGIEYVRQLVNLGSRTGLANKSGKTALHIAAMVDNYAAANILLAHSAK
VDAQDNQMRTPLYLACTEDAYRTAALLVRHCANKSAADVDDITPLMVAQR
KANHDIIRLFEANSPPHLMIPSPVSSNSTEMSPIYPDIRPKTHHMTTNQN
HQNNRKRKKPNVTTTYNMDPLRAMPEWSNPLNQTNQFTINHQQQTFPFNG
GSPFDTPSPYIVRQAELSPFSDTIPDIMTPPLSWTTSPNSEHEECG

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_004108	XLOC_004108	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00007329	TCONS_00007329	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR000742	EGF-like_dom
IPR011656	Notch_NODP_dom
IPR002110	Ankyrin_rpt
IPR000800	Notch_dom
IPR001881	EGF-like_Ca-bd_dom
IPR020683	Ankyrin_rpt-contain_dom
IPR013032	EGF-like_CS
IPR000152	EGF-type_Asp/Asn_hydroxyl_site
IPR018097	EGF_Ca-bd_CS

Vocabulary: **Biological Process**
Term	Definition
GO:0007275	multicellular organism development
GO:0030154	cell differentiation
GO:0007219	Notch signaling pathway

Vocabulary: **Cellular Component**
Term	Definition
GO:0016021	integral component of membrane

Vocabulary: **Molecular Function**
Term	Definition
GO:0005515	protein binding
GO:0005509	calcium ion binding

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0030154	cell differentiation
biological_process	GO:0007275	multicellular organism development
biological_process	GO:0007219	Notch signaling pathway
cellular_component	GO:0016021	integral component of membrane
molecular_function	GO:0005509	calcium ion binding
molecular_function	GO:0005515	protein binding

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000742	EGF-like domain	SMART	SM00181	egf_5	coord: 166..200 e-value: 0.0061 score: 25.8 coord: 205..243 e-value: 3.9E-5 score: 33.1 coord: 125..161 e-value: 210.0 score: 0.9 coord: 90..122 e-value: 2.0E-4 score: 30.7 coord: 248..280 e-value: 2.7E-6 score: 36.9
IPR000742	EGF-like domain	PFAM	PF00008	EGF	coord: 91..119 e-value: 5.3E-5 score: 23.3
IPR000742	EGF-like domain	PROSITE	PS50026	EGF_3	coord: 87..122 score: 15.062
IPR000742	EGF-like domain	PROSITE	PS50026	EGF_3	coord: 245..280 score: 15.927
IPR000742	EGF-like domain	PROSITE	PS50026	EGF_3	coord: 202..243 score: 18.019
IPR000742	EGF-like domain	PROSITE	PS50026	EGF_3	coord: 163..200 score: 15.463
IPR011656	Notch, NODP domain	SMART	SM01339	NODP_2	coord: 453..511 e-value: 0.003 score: 22.0
IPR011656	Notch, NODP domain	PFAM	PF07684	NODP	coord: 459..507 e-value: 2.1E-6 score: 27.6
IPR002110	Ankyrin repeat	SMART	SM00248	ANK_2a	coord: 657..687 e-value: 0.014 score: 24.6 coord: 691..720 e-value: 26.0 score: 13.7 coord: 724..753 e-value: 0.006 score: 25.8 coord: 625..653 e-value: 450.0 score: 7.6 coord: 757..786 e-value: 2.2 score: 17.3 coord: 790..819 e-value: 2400.0 score: 2.2
IPR002110	Ankyrin repeat	PROSITE	PS50088	ANK_REPEAT	coord: 657..690 score: 9.885
IPR002110	Ankyrin repeat	PROSITE	PS50088	ANK_REPEAT	coord: 691..723 score: 9.938
IPR002110	Ankyrin repeat	PROSITE	PS50088	ANK_REPEAT	coord: 724..756 score: 11.808
IPR000800	Notch domain	SMART	SM00004	NL_2	coord: 317..354 e-value: 0.19 score: 6.4 coord: 355..390 e-value: 0.022 score: 14.1
IPR000800	Notch domain	PFAM	PF00066	Notch	coord: 357..386 e-value: 1.7E-6 score: 28.2
IPR001881	EGF-like calcium-binding domain	SMART	SM00179	egfca_6	coord: 202..243 e-value: 0.0098 score: 18.0 coord: 163..200 e-value: 7.7E-9 score: 45.4 coord: 87..122 e-value: 0.0062 score: 19.6 coord: 246..280 e-value: 1.2E-5 score: 34.7
IPR001881	EGF-like calcium-binding domain	PFAM	PF07645	EGF_CA	coord: 163..206 e-value: 4.1E-7 score: 30.0
None	No IPR available	GENE3D	2.10.25.10		coord: 209..247 e-value: 1.7E-8 score: 33.8 coord: 125..162 e-value: 0.3 score: 10.7
None	No IPR available	GENE3D	2.10.25.10		coord: 248..284 e-value: 4.0E-10 score: 39.3
None	No IPR available	GENE3D	2.10.25.10		coord: 82..124 e-value: 8.0E-10 score: 37.9
None	No IPR available	GENE3D	2.10.25.10		coord: 163..208 e-value: 1.3E-10 score: 40.7
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 841..862
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 921..946
None	No IPR available	CDD	cd00054	EGF_CA	coord: 163..199 e-value: 2.29176E-6 score: 44.935
None	No IPR available	CDD	cd00054	EGF_CA	coord: 211..242 e-value: 1.26102E-4 score: 39.9274
None	No IPR available	CDD	cd00204	ANK	coord: 652..778 e-value: 2.99898E-29 score: 113.247
None	No IPR available	CDD	cd00054	EGF_CA	coord: 246..280 e-value: 7.338E-6 score: 43.3942
None	No IPR available	CDD	cd00054	EGF_CA	coord: 89..122 e-value: 0.00431783 score: 35.305
None	No IPR available	SUPERFAMILY	57196	EGF/Laminin	coord: 87..124
None	No IPR available	SUPERFAMILY	57196	EGF/Laminin	coord: 246..283
None	No IPR available	SUPERFAMILY	57196	EGF/Laminin	coord: 210..249
None	No IPR available	SUPERFAMILY	57196	EGF/Laminin	coord: 163..200
IPR020683	Ankyrin repeat-containing domain	GENE3D	1.25.40.20		coord: 611..718 e-value: 9.6E-25 score: 86.5
IPR020683	Ankyrin repeat-containing domain	PFAM	PF12796	Ank_2	coord: 670..755 e-value: 9.2E-11 score: 42.1
IPR020683	Ankyrin repeat-containing domain	GENE3D	1.25.40.20		coord: 719..890 e-value: 3.3E-22 score: 78.3
IPR020683	Ankyrin repeat-containing domain	PROSITE	PS50297	ANK_REP_REGION	coord: 625..810 score: 40.77
IPR020683	Ankyrin repeat-containing domain	SUPERFAMILY	48403	Ankyrin repeat	coord: 624..810
IPR013032	EGF-like, conserved site	PROSITE	PS00022	EGF_1	coord: 110..121
IPR013032	EGF-like, conserved site	PROSITE	PS00022	EGF_1	coord: 188..199
IPR013032	EGF-like, conserved site	PROSITE	PS01186	EGF_2	coord: 110..121
IPR013032	EGF-like, conserved site	PROSITE	PS01186	EGF_2	coord: 231..242
IPR013032	EGF-like, conserved site	PROSITE	PS00022	EGF_1	coord: 268..279
IPR013032	EGF-like, conserved site	PROSITE	PS01186	EGF_2	coord: 268..279
IPR013032	EGF-like, conserved site	PROSITE	PS00022	EGF_1	coord: 231..242
IPR000152	EGF-type aspartate/asparagine hydroxylation site	PROSITE	PS00010	ASX_HYDROXYL	coord: 259..270
IPR000152	EGF-type aspartate/asparagine hydroxylation site	PROSITE	PS00010	ASX_HYDROXYL	coord: 179..190
IPR018097	EGF-like calcium-binding, conserved site	PROSITE	PS01187	EGF_CA	coord: 163..188

Blast

[Close]

BLAST of TCONS_00007329-protein vs. Swiss-Prot (Human)
Match: NOTC3 (Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2)

HSP 1 Score: 194.897 bits (494), Expect = 1.214e-50
Identity = 227/864 (26.27%), Postives = 348/864 (40.28%), Query Frame = 0

Query:   97 NNGTCSQAQSNFTCICHDGWEGRLCE--IPKC-TLKCNHSKAQCNFRSPGKEQFCQCTIAGMTGASCESDINECNITETICHHGECENTPG-----SYKCHCDDFYTGPTCNDREDTCNTKSNKCHQNATCINEINSPEGYKCVCRNGYTGKYCDALVDN--------CAAANC-GNGQC----INKFNDYTCTCHDGYTGKNCETKI------KNESCPYDDCDRTQ----CDKRCNIPKCNYDAYLCTFNL-DPFKQCDIQECKNAINGT-CRSDCDNMNCLYDSGNC---IKPKKCS--LEEQCKKAYGDGVCHPLCNTVDCGFD-IDCISE-PNLIP-GSLVLEIDSTEGEFKAKKSQFEFELSRQLNSLVTVK-SVRTLNAGFKRKRRSISNNTSPRLE---------VTMKMDNSKCVS-----QCFSTEQ-AARFLALKSANDDLRLPVRVVKVSSKPSGEPPITPSISPLWIALIVVGAVCAIGVIYGAKTVKTR----FWKPEE-------TTGPGKRETPIGQEELQILD------------------ESRDSKRQKLGFDHSEPFLNG--MTDMNGMNGMHGLNINNMNNMNIGMIP------NDTIDQQQHHDN---PLHYAAH-HGIIHILRTQMDYVDVN-----------------KRDNTGRTALHVATSTGNDDIFAHLIRNRSINPDIQDDEGETP----------------------------------LMVAVRMAGIEYVRQLVNLGSRTGLANKSGKTALHIAAMVDNYAAANILLAHSAKVDAQDNQMRTPLYLACTEDAYRTAALLVRHCANKSAADVDDITPLMVAQRKANHDIIRLFE 811
            +NGTC      F C C  G+ G  CE  I +C +  C+ +  +   + PG    C C  AG +G  C++ ++ C  ++   H G+C  +PG     ++ CHC   + GP C     +C  +  +C     C     +P G +C C  G +G  C +   +        CAAA C   G C    +  F  + C C  G+TG  CE         +   CP   C   +    CD+ CN P C +D   C+ ++ DP++QC+  +C    N + C   C +  CLYD+ +C    + + C+   E+ C   + DG C   CNT +CG+D +DC SE P L+  G LVL +     E     + F   LS  L + +  +         F   R S  +    R E         V +++DN  C+       CF   Q AA +L   SA + L  P  +  V  +P  EPP  PS+  L + +     +  I V+      + R     W PE         +G   R  P+GQ+ L + +                  E  ++KR K+     EP +      D       H +  +      + + P       D +D      +   PL  A+   G +  + T+ D  D                   + D TG TALH+A      D    L+ +   + + QD  G TP                                  L++A R+A    V +L+   +     ++ GK+ALH AA V+N  A   LL + A  D QD++  TPL+LA  E +Y  A LL+ H AN+   D  D  P  VAQ + + DI+RL +
Sbjct: 1178 HNGTCVDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCH-AGFSGPRCQTVLSPCE-SQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSC--RELQCPVGVPCQQ---TPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPF--FRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCDPACSSPACLYDNFDCHAGGRERTCNPVYEKYCADHFADGRCDQGCNTEECGWDGLDCASEVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTSLRFRLDAHGQAMVFPYHRPSPGSEPRARRELAPEVIGSVVMLEIDNRLCLQSPENDHCFPDAQSAADYLGALSAVERLDFPYPLRDVRGEPL-EPP-EPSVPLLPLLVAGAVLLLVILVLGVMVARRKREHSTLWFPEGFSLHKDVASGHKGRREPVGQDALGMKNMAKGESLMGEVATDWMDTECPEAKRLKV----EEPGMGAEEAVDCRQWTQHHLVAADIRVAPAMALTPPQGDADADGMDVNVRGPDGFTPLMLASFCGGALEPMPTEEDEADDTSASIISDLICQGAQLGARTDRTGETALHLAARYARADAAKRLL-DAGADTNAQDHSGRTPLHTAVTADAQGVFQILIRNRSTDLDARMADGSTALILAARLAVEGMVEELIASHADVNAVDELGKSALHWAAAVNNVEATLALLKNGANKDMQDSKEETPLFLAAREGSYEAAKLLLDHFANREITDHLDRLPRDVAQERLHQDIVRLLD 2025

HSP 2 Score: 108.997 bits (271), Expect = 5.985e-24
Identity = 75/224 (33.48%), Postives = 104/224 (46.43%), Query Frame = 0

Query:   71 GHFTNLTDVGLN----STNASSDACHPHPCN-NGTCSQAQSNFTCICHDGWEGRLCEI--PKCTLKCNHSKAQCNFRSPGKEQFCQCTIAGMTGASCESDINECNITETICHHGECENTPGSYKCHCDDFYTGPTCNDREDTCNTKSNKCHQNATCINEINSPEGYKCVCRNGYTGKYCDALVDNCAAANCGNGQCINKFNDYTCTCHDGYTGKNCETKIKNES 287
            G F  + + G +    S + + DAC   PC   GTCS     F C C  G +GR CE+  P     C H   +C   +PG+   C C   G  G  C+ D++EC        HG C N  GS+ C C   YTGP+C+   + C+   N C    +C + + S   + C C  G+ G  C   VD C +  CG G C +    +TCTC  GY G +CE  + + S
Sbjct:  714 GGFRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHG-GRCE-SAPGQLPVCSCP-QGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDINDCDP--NPCLNGGSCQDGVGS---FSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCS 929

HSP 3 Score: 101.679 bits (252), Expect = 1.067e-21
Identity = 70/203 (34.48%), Postives = 94/203 (46.31%), Query Frame = 0

Query:   89 DACHPHPC-NNGTCSQA----QSNFTCICHDGWEGRLCEIPKCTLK--CNHSKAQCNFRSPGKEQFCQCTIAGMTGASCESDINECNITETICHHGECENTPGSYKCHCDDFYTGPTCNDREDTCNTKSNKCHQNATCINEINSPEGYKCVCRNGYTGKYCDALVDNCAAANCGN-GQCINKFNDYTCTCHDGYTGKNCETKI 283
            D CH  PC   G C  +     + F+C C  G+ G  C +P   L   C H  A+C+   P     C C   G  G SC SD++EC + E   H G C NTPGS++C C   YTGP C +    C    + C    TC    +    Y C C  G+ G+ C+  VD+C    C N G C++  N Y C C   +TG+ C   +
Sbjct:   80 DPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHG-ARCSV-GPDGRFLCSCP-PGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPC--APSPCRNGGTCRQSGDL--TYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDV 275

HSP 4 Score: 101.293 bits (251), Expect = 1.297e-21
Identity = 64/192 (33.33%), Postives = 98/192 (51.04%), Query Frame = 0

Query:   95 PCNN-GTCSQAQSNFTCICHDGWEGRLCE--IPKCTLKCNHSKAQCNFRSPGKEQFCQCTIAGMTGASCESDINECNITETICHHGECENTPGSYKCHCDDFYTGPTCNDREDTCNTKSNKCHQNATCINEINSPEGYKCVCRNGYTGKYCDALVDNCAAANCGNGQCINKFNDYTCTCHDGYTGKNCETKI 283
            PC + G C   Q +F C C  G+ G  CE  + +C      ++A C  R     QF    +AG TG  CE DI+EC  +  + + G C++    + C C   ++G TC    D C   S  C   A C+++   P+GY+C C  G+ G  CD  VD+C+   C +G+C++    ++C C  GYTG  CE+++
Sbjct:  401 PCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDR---IGQFTCICMAGFTGTYCEVDIDECQSSPCV-NGGVCKDRVNGFSCTCPSGFSGSTCQLDVDEC--ASTPCRNGAKCVDQ---PDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQV 583

HSP 5 Score: 91.6633 bits (226), Expect = 1.331e-18
Identity = 71/217 (32.72%), Postives = 91/217 (41.94%), Query Frame = 0

Query:   89 DACHPHPCNNGTCSQAQSNFTCICHDGWEGRLCEIPKCTLKCNHSKAQCNFRSPGKEQFCQ-------------CTIA-GMTGASCESDINECNITETICHHGECENTPGSYKCHCDDFYTGPTCNDREDTCNTKSNKCHQNATCINEINSPEGYKCVCRNGYTGKYCDALVDNC-------AAANC-GNGQCINKFNDYTCTCHDGYTGKNCETKI 283
            D C   PC NG     Q+   C+C  GW GRLC+I   +L C  + AQ   R    EQ CQ             C    G TG+ CE +++ C + +   H G C    G Y C C   Y G  C D  D C   S  C    +CI+ +     Y C C  G  G  C+   D+C       +   C  NG C++    + CTC  GYTG  CE  I
Sbjct: 1002 DWCSRQPCQNGG-RCVQTGAYCLCPPGWSGRLCDIR--SLPCREAAAQIGVR---LEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPC-LAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDEC--ASQPCQHGGSCIDLVAR---YLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTGLRCEADI 1206

HSP 6 Score: 87.4261 bits (215), Expect = 2.701e-17
Identity = 59/208 (28.37%), Postives = 95/208 (45.67%), Query Frame = 0

Query:   89 DACHPHPCNNGTCSQAQSNFTCICHDGWEGRLCE--IPKC-TLKCNHSKAQCNFRSPGKEQFCQCTIAGMTGASCESDINECNITETICHHGECENTPGSYKCHCDDFYTGPTCNDREDTCNTKSNKCHQNATCINEINSPEGYKCVCRNGYTGKYCDALVDNCAAANCGNGQCINKFNDYTCTCHDGYTGKNCETKIKNESCPYDDC 293
            D C P PC++G C    ++F+C C  G+ G  CE  + +C +  C H     +      +  C+C  +G TG +CE +I++C      C  G C +    Y C C   +TGP CN   + C   S+ C +  +C++  N   G++C+C  G     C      CA   C +G C +    + C C  G++G  C   +  ++C    C
Sbjct:  547 DDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLV---DKYLCRCP-SGTTGVNCEVNIDDC--ASNPCTFGVCRDGINRYDCVCQPGFTGPLCNVEINEC--ASSPCGEGGSCVDGEN---GFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPGWSGPRCSQSLARDACESQPC 743

The following BLAST results are available for this feature:

BLAST of TCONS_00007329-protein vs. Swiss-Prot (Human)

BLAST of TCONS_00007329-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
NOTC3	1.214e-50	26.27	Neurogenic locus notch homolog protein 3 OS=Homo s...	[more]

You are here

TCONS_00007329-protein (polypeptide) - C. hemisphaerica