Multidrug resistance associated protein (polypeptide) - C. hemisphaerica

Overview


Name	Multidrug resistance associated protein
Unique Name	TCONS_00012747-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	1147

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00012747-protein ID=TCONS_00012747-protein|Name=Multidrug resistance associated protein|organism=Clytia hemisphaerica|type=polypeptide|length=1147bp
METLKNPKRCDKRRFENANFLERQFFTYISPTFREGNKRVLEPQDIAGIE
ENHKSAVVVERLRSIWSIEKQHSKEAGKKPSFFRAMLLYAFPTMVRAGLF
AFAQICLRILQPFLLKQVIDSISNKSKQEDAVYWGLGLVATLLITPNLHP
HVFLVQELLGTDIKSAGLTLIFKKALRVHQGGISKITTGKLVTLVSTDAQ
KLQEGLYLFHSLWVGPLVIIATTAILWQALGPSCLAGISILILMIPLQSF
FGKTFAKLRSKTVGKTDQRVNTMNEIISSMQVTKMYTWENSFAKMISDIR
KKETNCVMRSAMLKAFNMAFSMSSNYIVLFATFSTYYFHGSGHVTLGLLF
QAMSLFFLVRTESLLLFPIGFQLLMESKIGCQRIAQFLLTEEMEEKSEVK
KTSEPKMDFDNVTASWTEESEEILKSVSFSVNEKNKLMMLVGPVGSGKSS
ILNAALREMSIKKGSINTQGKVVYTSQQSWIFSSTIRQNIIFGNEFDVER
YKRVIDACALKTDLKLFEKGDLTLVGERGVSLSGGQKARIGLARAVYQNA
DIYLLDDPLSAVDTKVARHIFEKCINGLLKNKLKVLVTHQIQYLQHASSI
YTMKEGNAVKISLEEIVELGIDIGQDEDDVAEDQDKLEREHEDHHDHHKE
NLHLEVLDEDLEDMATLACSTSFERSSIRYRLSRSNSRKSINSMVFAEEE
LDNEANSKEEKQTKQGAVKADIYYQYYKDGLGWFVTLCLFLGIVFVQVLF
TMTDYFMASWARSEEQRARNEPITDSFIFTDNPTNNIYTFAVLAFLTLIC
NYLRTAGYFISLVKCSRVAHNSMFDAVLKSPIYFFDTNPVGQILNRFSRD
IFQMDDELPWKSFDAINNGVLMTTLVAVNIVSMPYLLIIVVPLAVIFYKF
REYYMKTSRQIRRLEASSRSPLYTHISATFSGLTTIRAFDKQDKIMEEFF
TCQDYQASAWIVFVRASRWFCYRLDMMAAIFGVVAVLATTIAVRYTDVDP
GLAGISLSYVMILPGLFQWAIRQSTEVSNLMVAVERVREYSQLEAEEDVG
NNEKIPKGWPSRASITASKASFQYHHTLPAVLKQVNFEIKEGEKIGIVGR
TGAGKSSLLNMLFRMGKNNGAIKIDGYDIQNLKLQTLRNAISVIPQV

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_007147	XLOC_007147	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00012747	TCONS_00012747	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR003593	AAA+_ATPase
IPR003439	ABC_transporter-like
IPR011527	ABC1_TM_dom
IPR017871	ABC_transporter_CS
IPR027417	P-loop_NTPase

Vocabulary: **Molecular Function**
Term	Definition
GO:0016887	ATPase activity
GO:0005524	ATP binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Vocabulary: **Biological Process**
Term	Definition
GO:0055085	transmembrane transport
GO:0006810	transport

Vocabulary: **Cellular Component**
Term	Definition
GO:0016021	integral component of membrane

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0055085	transmembrane transport
biological_process	GO:0006810	transport
cellular_component	GO:0016021	integral component of membrane
molecular_function	GO:0016887	ATPase activity
molecular_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances
molecular_function	GO:0005524	ATP binding

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 694..714
None	No IPR available	GENE3D	3.40.50.300		coord: 393..618 e-value: 3.7E-50 score: 170.1 coord: 1049..1147 e-value: 1.1E-20 score: 73.5
None	No IPR available	GENE3D	1.20.1560.10		coord: 696..1048 e-value: 2.6E-59 score: 200.2 coord: 62..392 e-value: 3.5E-53 score: 180.0
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 629..651
None	No IPR available	CDD	cd03250	ABCC_MRP_domain1	coord: 407..606 e-value: 3.66846E-101 score: 319.03
IPR003593	AAA+ ATPase domain	SMART	SM00382	AAA_5	coord: 434..784 e-value: 2.3E-9 score: 47.1
IPR003439	ABC transporter-like	PFAM	PF00005	ABC_tran	coord: 1082..1146 e-value: 9.6E-15 score: 55.2 coord: 424..559 e-value: 2.5E-17 score: 63.6
IPR003439	ABC transporter-like	PROSITE	PS50893	ABC_TRANSPORTER_2	coord: 407..630 score: 19.428
IPR011527	ABC transporter type 1, transmembrane domain	PFAM	PF00664	ABC_membrane	coord: 97..359 e-value: 1.3E-30 score: 106.9 coord: 739..1013 e-value: 4.4E-33 score: 115.0
IPR011527	ABC transporter type 1, transmembrane domain	PROSITE	PS50929	ABC_TM1F	coord: 772..1029 score: 29.73
IPR011527	ABC transporter type 1, transmembrane domain	PROSITE	PS50929	ABC_TM1F	coord: 97..359 score: 29.829
IPR011527	ABC transporter type 1, transmembrane domain	SUPERFAMILY	90123	ABC transporter transmembrane region	coord: 737..1046
IPR011527	ABC transporter type 1, transmembrane domain	SUPERFAMILY	90123	ABC transporter transmembrane region	coord: 84..392
IPR017871	ABC transporter, conserved site	PROSITE	PS00211	ABC_TRANSPORTER_1	coord: 532..546
IPR027417	P-loop containing nucleoside triphosphate hydrolase	SUPERFAMILY	52540	P-loop containing nucleoside triphosphate hydrolases	coord: 1056..1146
IPR027417	P-loop containing nucleoside triphosphate hydrolase	SUPERFAMILY	52540	P-loop containing nucleoside triphosphate hydrolases	coord: 402..610

Blast

[Close]

BLAST of Multidrug resistance associated protein vs. Swiss-Prot (Human)
Match: MRP4 (Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3)

HSP 1 Score: 800.431 bits (2066), Expect = 0.000e+0
Identity = 435/1142 (38.09%), Postives = 671/1142 (58.76%), Query Frame = 0

Query:   15 FENANFLERQFFTYISPTFREGNKRVLEPQDIAGIEENHKSAVVVERLRSIWSIEKQHSKEAGKKPSFFRAMLLYAFPTMVRAGLFAFAQICLRILQPFLLKQVIDSISNKSKQED-----AVYWGLGLVATLLITPNLHPHVFLVQELLGTDIKSAGLTLIFKKALRVHQGGISKITTGKLVTLVSTDAQKLQEGLYLFHSLWVGPLVIIATTAILWQALGPSCLAGISILILMIPLQSFFGKTFAKLRSKTVGKTDQRVNTMNEIISSMQVTKMYTWENSFAKMISDIRKKETNCVMRSAMLKAFNMAFSMSSNYIVLFATFSTYYFHGSGHVTLGLLFQAMSLFFLVRTESLLLFPIGFQLLMESKIGCQRIAQFLLTEEMEEKSEVKKTSEPKM-DFDNVTASWTEESE-EILKSVSFSVNEKNKLMMLVGPVGSGKSSILNAALREMSIKKGSINTQGKVVYTSQQSWIFSSTIRQNIIFGNEFDVERYKRVIDACALKTDLKLFEKGDLTLVGERGVSLSGGQKARIGLARAVYQNADIYLLDDPLSAVDTKVARHIFEKCINGLLKNKLKVLVTHQIQYLQHASSIYTMKEGNAV-KISLEEIVELGIDIGQDEDDVAEDQDKLEREHEDHHDHHKENLHLEVLDEDLEDMATLACSTSFERSSIRYRLSRSNSRKSINSMVFAEEELDNEANSKEEKQTKQGAVKADIYYQYYKDGLGWFVTLCLFLGIVFVQVLFTMTDYFMASWARSEEQRARNEPITDSFIFTDNPTNNIY--TFAVLAFLTLICNYLRTAGYFISLVKCSRVAHNSMFDAVLKSPIYFFDTNPVGQILNRFSRDIFQMDDELPWKSFDAINNGVLMTTLVAVNIVSMPYLLIIVVPLAVIFYKFREYYMKTSRQIRRLEASSRSPLYTHISATFSGLTTIRAFDKQDKIMEEFFTCQDYQASAWIVFVRASRWFCYRLDMMAAIFGVVAVLATTIAVRYTDVDPGLAGISLSYVMILPGLFQWAIRQSTEVSNLMVAVERVREYSQLEAEEDVGNNEKIPKGWPSRASITASKASFQYHHTLPAVLKQVNFEIKEGEKIGIVGRTGAGKSSLLNMLFRMGKNNGAIKIDGYDIQNLKLQTLRNAISVIPQ 1146
             ++AN   R FF +++P F+ G+KR LE  D+  +    +S  + E L+  W  E   ++   +KPS  RA++   + + +  G+F   +   +++QP  L ++I+   N    +      A  +   L    LI   LH   F   +  G  ++ A   +I++KALR+    + K TTG++V L+S D  K  +     H LW GPL  IA TA+LW  +G SCLAG+++LI+++PLQS FGK F+ LRSKT   TD R+ TMNE+I+ +++ KMY WE SF+ +I+++RKKE + ++RS+ L+  N+A   S++ I++F TF+TY   GS  +T   +F A++L+  VR    L FP   + + E+ +  +RI  FLL +E+ +++    +   KM    + TA W + SE   L+ +SF+V    +L+ +VGPVG+GKSS+L+A L E++   G ++  G++ Y SQQ W+FS T+R NI+FG +++ ERY++VI ACALK DL+L E GDLT++G+RG +LSGGQKAR+ LARAVYQ+ADIYLLDDPLSAVD +V+RH+FE CI  +L  K+ +LVTHQ+QYL+ AS I  +K+G  V K +  E ++ GID G            L++++E+                 +    TL   T F  SS+    S+ +SR S+       ++ +N   +  E+   +G V    Y  Y++ G  W V + L L     QV + + D++++ WA   +Q   N  +      T+    N Y   ++ L   T++    R+   F  LV  S+  HN MF+++LK+P+ FFD NP+G+ILNRFS+DI  +DD LP    D I   + +  +V+V +  +P++ I +VPL +IF   R Y+++TSR ++RLE+++RSP+++H+S++  GL TIRA+  +++  E F   QD  + AW +F+  SRWF  RLD + A+F ++    + I  +   +D G  G++LSY + L G+FQW +RQS EV N+M++VERV EY+ LE E      ++ P  WP    I     +F Y    P VLK +   IK  EK+GIVGRTGAGKSSL++ LFR+ +  G I ID      + L  LR  +S+IPQ
Sbjct:   13 LQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSV-ITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTV-RPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFG----------SLLKKDNEESE------------QPPVPGTPTLRNRT-FSESSV---WSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFRAGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWA--NKQSMLNVTVNGGGNVTEKLDLNWYLGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAK--TLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQ 1122

The following BLAST results are available for this feature:

BLAST of Multidrug resistance associated protein vs. Swiss-Prot (Human)

BLAST of Multidrug resistance associated protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
MRP4	0.000e+0	38.09	Multidrug resistance-associated protein 4 OS=Homo ...	[more]

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Multidrug resistance associated protein (polypeptide) - C. hemisphaerica