TCONS_00026127-protein (polypeptide) - C. hemisphaerica

Overview


Name	TCONS_00026127-protein
Unique Name	TCONS_00026127-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	568

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00026127-protein ID=TCONS_00026127-protein|Name=TCONS_00026127-protein|organism=Clytia hemisphaerica|type=polypeptide|length=568bp
MHFISLCSILIAVFPMVKNQQSRHSCKKVDPTNAECLQDINKCSNVTCEE
DDNHCMTVYKLEKGRFVPFFGGCFGTPHDQSTTSHNKCVLYQRNPHYPTH
YDCFCSGSFCNANIIFPQIKSTTEQPVRNTTKALSSLQPTQRTDSSEKLY
LYYIPASIFLMTMVLGVALFFWIKRKRRRRNSHETLLTEFNTTMTQPKTY
PASFLEIIHQGQMNTIWKATFCQRAAAIKIVNKLDVTQWVNEKDIFLNHK
LKHDNVVNFISAERRFKETTVQYWIVTEYHEKGSLANYLLKNILSKETFL
RMLYSTVKGLVYLHSNSKMKPMVAHRDLKPANVLVKADLSCCICDLGLAL
PLPENIDVSRELCQAGTKRYMAPEILQGAVTFYQESFLRADMYSMGLLFW
DLLSRTKIDESIEVEEYKPPYSGLVNFNPSVDEMLKCVVENHKRPHIPNH
WKETQSFVTIVETMELCWDDDADARLTSQCVAQRIRRLIHSPPDNTFQSH
ALEQLKEGEKENSQSSSISSNSALLWDNSSTRKDCTSNKSIGSYSTTDDH
SQYSLSSSSNTVLTKCNA

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_014692	XLOC_014692	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00026127	TCONS_00026127	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR000333	TGFB_receptor
IPR000719	Prot_kinase_dom
IPR017194	Transform_growth_fac-b_typ-2
IPR008271	Ser/Thr_kinase_AS
IPR011009	Kinase-like_dom

Vocabulary: **Molecular Function**
Term	Definition
GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0005524	ATP binding
GO:0004672	protein kinase activity
GO:0004872	receptor activity
GO:0046872	metal ion binding
GO:0004674	protein serine/threonine kinase activity

Vocabulary: **Biological Process**
Term	Definition
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0006468	protein phosphorylation
GO:0007179	transforming growth factor beta receptor signaling pathway

Vocabulary: **Cellular Component**
Term	Definition
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0006468	protein phosphorylation
biological_process	GO:0007179	transforming growth factor beta receptor signaling pathway
biological_process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
cellular_component	GO:0016021	integral component of membrane
cellular_component	GO:0016020	membrane
cellular_component	GO:0043235	receptor complex
molecular_function	GO:0005524	ATP binding
molecular_function	GO:0046872	metal ion binding
molecular_function	GO:0004672	protein kinase activity
molecular_function	GO:0004674	protein serine/threonine kinase activity
molecular_function	GO:0004872	receptor activity
molecular_function	GO:0004702	signal transducer, downstream of receptor, with serine/threonine kinase activity

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000333	Ser/Thr protein kinase, TGFB receptor	PRINTS	PR00653	ACTIVIN2R	coord: 456..475 score: 48.0 coord: 91..114 score: 28.33 coord: 336..357 score: 36.67
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 202..489 e-value: 1.8E-14 score: 64.1
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 207..414 e-value: 8.9E-31 score: 107.1
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 202..489 score: 33.22
None	No IPR available	GENE3D	1.10.510.10		coord: 294..554 e-value: 2.3E-34 score: 117.9
None	No IPR available	GENE3D	2.10.60.10		coord: 18..119 e-value: 4.5E-9 score: 36.1
None	No IPR available	GENE3D	3.30.200.20		coord: 195..293 e-value: 1.4E-9 score: 37.2
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 531..568
None	No IPR available	SUPERFAMILY	57302	Snake toxin-like	coord: 26..115
IPR017194	Transforming growth factor-beta receptor, type II	PIRSF	PIRSF037393	TGFRII	coord: 179..514 e-value: 3.3E-70 score: 234.9 coord: 3..185 e-value: 0.3 score: 7.3
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 323..335
IPR011009	Protein kinase-like domain	SUPERFAMILY	56112	Protein kinase-like (PK-like)	coord: 189..484

Blast

[Close]

BLAST of TCONS_00026127-protein vs. Swiss-Prot (Human)
Match: AVR2B (Activin receptor type-2B OS=Homo sapiens GN=ACVR2B PE=1 SV=3)

HSP 1 Score: 249.98 bits (637), Expect = 4.568e-76
Identity = 153/471 (32.48%), Postives = 236/471 (50.11%), Query Frame = 0

Query:   37 LQDINKCSNVTCEEDDN---HCMTVYKLEKGRFVPFFGGCFGTPHDQSTTSHNKCVLYQRNPHYPTHYDCFCSGSFCNANIIFPQIKSTTEQPVRNTTKALSSLQPTQRTDSSEKLYLYYIPASIFLMTMVLGVALFFWIKRKRR----RRNSHETLLTEFNTTMTQPKTYPASFLEIIHQGQMNTIWKATFCQRAAAIKIVNKLDVTQWVNEKDIFLNHKLKHDNVVNFISAERRFKETTVQYWIVTEYHEKGSLANYLLKNILSKETFLRMLYSTVKGLVYLHSN------SKMKPMVAHRDLKPANVLVKADLSCCICDLGLALPLPENIDVSRELCQAGTKRYMAPEILQGAVTFYQESFLRADMYSMGLLFWDLLSRTKIDESIEVEEYKPPYSGLVNFNPSVDEMLKCVVENHKRPHIPNHWKETQSFVTIVETMELCWDDDADARLTSQCVAQR---IRRLIHS 491
            L+  N+     CE + +   HC   ++   G       GC+    D +     +CV  + NP     Y C C G+FCN           T  P     +      PT  T  +    L Y    I  ++++  V L FW+ R R+      + HE       + +   K  P   LEI  +G+   +WKA       A+KI    D   W +E++IF    +KH+N++ FI+AE+R     V+ W++T +H+KGSL +YL  NI++      +  +  +GL YLH +         KP +AHRD K  NVL+K+DL+  + D GLA+             Q GT+RYMAPE+L+GA+ F +++FLR DMY+MGL+ W+L+SR K  +   V+EY  P+   +  +PS++E+ + VV    RP I +HW +      +  T+E CWD DA+ARL++ CV +R   IRR ++ 
Sbjct:   38 LERTNQSGLERCEGEQDKRLHCYASWRNSSGTIELVKKGCW--LDDFNCYDRQECVATEENPQV---YFCCCEGNFCNERF--------THLPEAGGPEVTYEPPPTAPTLLT---VLAYSLLPIGGLSLI--VLLAFWMYRHRKPPYGHVDIHEDPGPPPPSPLVGLK--PLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADG-PVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVNG 487

The following BLAST results are available for this feature:

BLAST of TCONS_00026127-protein vs. Swiss-Prot (Human)

BLAST of TCONS_00026127-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
AVR2B	4.568e-76	32.48	Activin receptor type-2B OS=Homo sapiens GN=ACVR2B...	[more]

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TCONS_00026127-protein (polypeptide) - C. hemisphaerica