TCONS_00028269-protein (polypeptide) - C. hemisphaerica

Overview
NameTCONS_00028269-protein
Unique NameTCONS_00028269-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length663

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00028269-protein ID=TCONS_00028269-protein|Name=TCONS_00028269-protein|organism=Clytia hemisphaerica|type=polypeptide|length=663bp
SGFVNIRAVPEEMELAREEKCEFLPFVTPKEVVVKGDRIAAMEFFKTEQL
DDGTWIEDEDQTLKIKANFIISAFGSTLAQKDVIEALSPLKMNRWGLPDV
NQDTMGSSEADVFCGGDIGGQANTTVESVNDGKHASWSMHRYLQQLAGVS
IPPEPKLPLFCTPIDEVDLSVEMCGLKFPNPFGLASAPPTTSAPMMRRAY
EAGWGFELTKTFVLDKDYIVNVSPRIVRGSTSGHLYGPGQGAFLNIELIS
EKSAEYWCKSITELVTDFPDKVLIASIMCTYTKEDWQELTIMAQDAGAHA
LELNLSCPHGMGEKGMGLACGQDSMLVRNICKWVREVATIPFFAKLTPNV
TNIVDIARAAKEGGADGVTATNTVSGLMHLKGDASPWPGVGKAKRTTYGG
VSGNAIRPIALRAVSAIARALPGFPILATGGIDSADAALQFLHAGASVVQ
ICSSVQNQDFTVIQDYITGLQTLLYMDACDAFKGWNGQSEPTVRHQKGKP
VPVATKVNEVIGKGLPHFGEFKKQRDAAMSEHKKNADLHSQENMPEKVRP
PTEPQRNMTTIQDMIGRSLKHIGAYNDLTNKEQVVACIDDEMCINCGKCY
MTCNDSGYQAITFDPDTHIPHVTEDCTGCTLCVSVCPIIDCIEMVPKQIP
HVINRGIPLKINV
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_016014XLOC_016014Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00028269TCONS_00028269Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR005720Dihydroorotate_DH
IPR013785Aldolase_TIM
IPR023753FAD/NAD-binding_dom
IPR001295Dihydroorotate_DH_CS
IPR0179004Fe4S_Fe_S_CS
IPR0178964Fe4S_Fe-S-bd
Vocabulary: Molecular Function
TermDefinition
GO:0016627oxidoreductase activity, acting on the CH-CH group of donors
GO:0003824catalytic activity
GO:0016491oxidoreductase activity
GO:0004152dihydroorotate dehydrogenase activity
Vocabulary: Biological Process
TermDefinition
GO:0055114oxidation-reduction process
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process
Vocabulary: Cellular Component
TermDefinition
GO:0005737cytoplasm
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
biological_process GO:0055114 oxidation-reduction process
cellular_component GO:0005737 cytoplasm
molecular_function GO:0003824 catalytic activity
molecular_function GO:0004152 dihydroorotate dehydrogenase activity
molecular_function GO:0016491 oxidoreductase activity
molecular_function GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3D3.30.70.20coord: 549..653
e-value: 2.2E-17
score: 62.2
NoneNo IPR availablePFAMPF14697Fer4_21coord: 586..644
e-value: 4.1E-22
score: 78.0
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 529..555
NoneNo IPR availableCDDcd02940DHPD_FMNcoord: 168..470
e-value: 0.0
score: 523.0
NoneNo IPR availableSUPERFAMILY51395FMN-linked oxidoreductasescoord: 169..475
NoneNo IPR availableSUPERFAMILY548624Fe-4S ferredoxinscoord: 559..650
IPR005720Dihydroorotate dehydrogenase domainTIGRFAMTIGR01037TIGR01037coord: 169..482
e-value: 2.2E-49
score: 166.1
IPR005720Dihydroorotate dehydrogenase domainPFAMPF01180DHO_dhcoord: 169..474
e-value: 1.4E-34
score: 119.6
IPR013785Aldolase-type TIM barrelGENE3D3.20.20.70coord: 169..480
e-value: 1.8E-55
score: 187.9
IPR023753FAD/NAD(P)-binding domainGENE3D3.50.50.60coord: 13..168
e-value: 1.3E-15
score: 57.0
IPR023753FAD/NAD(P)-binding domainSUPERFAMILY51905FAD/NAD(P)-binding domaincoord: 6..75
IPR023753FAD/NAD(P)-binding domainSUPERFAMILY51905FAD/NAD(P)-binding domaincoord: 48..144
IPR001295Dihydroorotate dehydrogenase, conserved sitePROSITEPS00912DHODEHASE_2coord: 426..446
IPR0179004Fe-4S ferredoxin, iron-sulphur binding, conserved sitePROSITEPS001984FE4S_FER_1coord: 626..637
IPR0178964Fe-4S ferredoxin-type, iron-sulphur binding domainPROSITEPS513794FE4S_FER_2coord: 618..647
score: 9.751
IPR0178964Fe-4S ferredoxin-type, iron-sulphur binding domainPROSITEPS513794FE4S_FER_2coord: 584..616
score: 8.197

Blast
[Close]
BLAST of TCONS_00028269-protein vs. Swiss-Prot (Human)
Match: DPYD (Dihydropyrimidine dehydrogenase [NADP(+)] OS=Homo sapiens GN=DPYD PE=1 SV=2)

HSP 1 Score: 939.102 bits (2426), Expect = 0.000e+0
Identity = 440/661 (66.57%), Postives = 539/661 (81.54%), Query Frame = 0 
Query:    2 GFVNIRAVPEEMELAREEKCEFLPFVTPKEVVVKGDRIAAMEFFKTEQLDDGTWIEDEDQTLKIKANFIISAFGSTLAQKDVIEALSPLKMNRWGLPDVNQDTMGSSEADVFCGGDIGGQANTTVESVNDGKHASWSMHRYLQQLAGVSIPPEPKLPLFCTPIDEVDLSVEMCGLKFPNPFGLASAPPTTSAPMMRRAYEAGWGFELTKTFVLDKDYIVNVSPRIVRGSTSGHLYGPGQGAFLNIELISEKSAEYWCKSITELVTDFPDKVLIASIMCTYTKEDWQELTIMAQDAGAHALELNLSCPHGMGEKGMGLACGQDSMLVRNICKWVREVATIPFFAKLTPNVTNIVDIARAAKEGGADGVTATNTVSGLMHLKGDASPWPGVGKAKRTTYGGVSGNAIRPIALRAVSAIARALPGFPILATGGIDSADAALQFLHAGASVVQICSSVQNQDFTVIQDYITGLQTLLYMDACDAFKGWNGQSEPTVRHQKGKPVPVATKVNEVIGKGLPHFGEFKKQRDAAMSEHKKNADLHSQENMPEKVRPPTEPQRNMTTIQDMIGRSLKHIGAYNDLTNKEQVVACIDDEMCINCGKCYMTCNDSGYQAITFDPDTHIPHVTEDCTGCTLCVSVCPIIDCIEMVPKQIPHVINRGIPLKIN 662
            GFVNIRAVPEEMELA+EEKCEFLPF++P++V+VKG RI AM+F +TEQ + G W EDEDQ + +KA+ +ISAFGS L+   V EALSP+K NRWGLP+V+ +TM +SEA VF GGD+ G ANTTVESVNDGK ASW +H+Y+Q   G S+  +P+LPLF TPID VD+SVEM GLKF NPFGLASA P TS  M+RRA+EAGWGF LTKTF LDKD + NVSPRI+RG+TSG +YGPGQ +FLNIELISEK+A YWC+S+TEL  DFPD ++IASIMC+Y K DW EL   ++D+GA ALELNLSCPHGMGE+GMGLACGQD  LVRNIC+WVR+   IPFFAKLTPNVT+IV IARAAKEGGA+GVTATNTVSGLM LK D +PWP VG AKRTTYGGVSG AIRPIALRAV++IARALPGFPILATGGIDSA++ LQFLH+GASV+Q+CS++QNQDFTVI+DY TGL+ LLY+ + +  + W+GQS  TV HQKGKPVP   ++ E++ K LP FG + +QR   ++E+K      +    P K R    P+R + TI+D+IG++L+++G + +L+N EQVVA ID+EMCINCGKCYMTCNDSGYQAI FDP+TH+P +T+ CTGCTLC+SVCPI+DCI+MV +  P+   RG+PL +N
Sbjct:  366 GFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVP---RIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSPLK-RNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLSVN 1022
The following BLAST results are available for this feature:
BLAST of TCONS_00028269-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
DPYD0.000e+066.57Dihydropyrimidine dehydrogenase [NADP(+)] OS=Homo ... [more]
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