TCONS_00049205-protein (polypeptide) - C. hemisphaerica

Overview
NameTCONS_00049205-protein
Unique NameTCONS_00049205-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length1137

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00049205-protein ID=TCONS_00049205-protein|Name=TCONS_00049205-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1137bp
MSGETGRNGDVNGSTADVSTNGGTGCPFLNGGSNEPTSRYASRPFVLKNL
LEGSTMTDTLHQKAVGTVPCDQKTCLGSIYMPSNDDVPPGEMRPKEEVKK
HATVFLNEYYTSLKKQNSESHVQRLKQVISEIDQTSTYELDIKELEFGAR
LAWRNAPRCNGRIQWKKLTLFDCRHVETASDMFGCITRHIQYATNKGNLR
STITIFPHKKSAMSEYRVWNSQLVRYAGYRQKDGTVIGDPASVELTEVCK
KLGWKGYGGHFDIIPMVLSAPGQPPELFEIPKDIVLEVPITHPHYPIDKL
GLKWYAIPAVANMMLDIGGLQFTACPFSGWYNATEIGARNFTDTCRYNLM
KPAAELCGFDTSNMATLWKDKIAVELTVAVIHSFQKSGVTIVDHHSSAET
FMKHIKDEEKLRGGCPTDWVWVVPPLTGGIMPMFHQEFLNYKLRPSYEYQ
PDPWKYLPNAKLQNENESEGKGYPKRRFKDVVKAVKFSSSMMSRAMEKRS
KATILYATETGKSEKFANTLNEILLFAFDSKVVCMEDYDVSDLPHEQCVI
IVTSTFGNGESPDNGRSFQDGLEAMIAETASSSLSTESLEILTNVRFAVF
GLGSRAYPNFCSFAHIVKRLLKSLGGEEIHETGEGDELCGQESSFNEWAA
GAFKAACDSFGIYDVDMKAAISSIASSAKDWKKGLFRLSKTPVGNESIPE
ALSKLHRKKVVPAKCISVQNLQSSQSDRVTNLVKIDRCGHDEIMYKAGDH
LSVYPTNEKVLVDALLDRVICDVGYDDCVTMEIKEVDKWVQSNKIPFVTT
LRQMITSYLDITSPPSPKLLAVFSEEATNEEEKYELELLSTDNDKYEDWS
HANYPNIVEVLEKFKSVACDVTMLINHLPLLNPRHYSISSSQDLHPSEVH
VTVALVSYEIKGNTHNGVCSYYLSNLKPNDVVYCNIRKASSFYLPTDRSS
PVIMIGPGTGIAPFRSFWQQALFEHTENKDSVKRDMTLYFGCRNSKHDDI
YAKETTELVNQKILSSVRTAYSREENLPKTYVQQILHQDMEKVGETILDK
QGHVYVCGDVTMASDVSKMITKILQEYAALSDEEAKQFISELRTSKRYHE
DIFGVTLKVKEVTEKVRKGSKRLRKQKTLTKQLTLNS
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_031247XLOC_031247Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00049205TCONS_00049205Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR001709Flavoprot_Pyr_Nucl_cyt_Rdtase
IPR001094Flavdoxin-like
IPR003097FAD-binding_1
IPR012144NOS_euk
IPR001433OxRdtase_FAD/NAD-bd
IPR008254Flavodoxin/NO_synth
IPR029039Flavoprotein-like_dom
IPR004030NOS_N
IPR017927Fd_Rdtase_FAD-bd
IPR017938Riboflavin_synthase-like_b-brl
Vocabulary: Biological Process
TermDefinition
GO:0055114oxidation-reduction process
GO:0006809nitric oxide biosynthetic process
Vocabulary: Molecular Function
TermDefinition
GO:0016491oxidoreductase activity
GO:0010181FMN binding
GO:0005506iron ion binding
GO:0050660flavin adenine dinucleotide binding
GO:0005516calmodulin binding
GO:0050661NADP binding
GO:0020037heme binding
GO:0004517nitric-oxide synthase activity
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0006809 nitric oxide biosynthetic process
biological_process GO:0055114 oxidation-reduction process
molecular_function GO:0005516 calmodulin binding
molecular_function GO:0050660 flavin adenine dinucleotide binding
molecular_function GO:0010181 FMN binding
molecular_function GO:0020037 heme binding
molecular_function GO:0005506 iron ion binding
molecular_function GO:0050661 NADP binding
molecular_function GO:0004517 nitric-oxide synthase activity
molecular_function GO:0016491 oxidoreductase activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001709Flavoprotein pyridine nucleotide cytochrome reductasePRINTSPR00371FPNCRcoord: 953..972
score: 60.52
coord: 1029..1045
score: 25.42
coord: 1053..1061
score: 50.06
coord: 745..755
score: 40.44
coord: 884..891
score: 67.53
coord: 917..926
score: 38.97
coord: 984..993
score: 40.34
IPR001094Flavodoxin-likePRINTSPR00369FLAVODOXINcoord: 503..516
score: 49.55
coord: 550..561
score: 47.27
coord: 594..604
score: 61.79
coord: 618..637
score: 35.62
IPR003097FAD-binding, type 1PFAMPF00667FAD_binding_1coord: 705..922
e-value: 1.0E-56
score: 191.9
NoneNo IPR availableGENE3D2.40.30.10coord: 695..935
e-value: 2.1E-46
score: 157.9
NoneNo IPR availableGENE3D3.90.1230.10coord: 287..396
e-value: 4.1E-45
score: 152.0
NoneNo IPR availableGENE3D3.40.50.80coord: 950..1104
e-value: 4.6E-38
score: 130.1
NoneNo IPR availableGENE3D3.90.340.10coord: 58..219
e-value: 1.0E-56
score: 190.6
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..40
NoneNo IPR availableSUPERFAMILY52343Ferredoxin reductase-like, C-terminal NADP-linked domaincoord: 941..1104
IPR012144Nitric-oxide synthase, eukaryotePIRSFPIRSF000333INOScoord: 577..1130
e-value: 2.0E-200
score: 666.0
coord: 30..590
e-value: 2.0E-255
score: 848.2
IPR001433Oxidoreductase FAD/NAD(P)-bindingPFAMPF00175NAD_binding_1coord: 954..1068
e-value: 8.0E-19
score: 68.2
IPR008254Flavodoxin/nitric oxide synthasePFAMPF00258Flavodoxin_1coord: 504..648
e-value: 8.5E-42
score: 142.6
IPR008254Flavodoxin/nitric oxide synthasePROSITEPS50902FLAVODOXIN_LIKEcoord: 502..653
score: 28.703
IPR029039Flavoprotein-like domainGENE3D3.40.50.360coord: 460..674
e-value: 7.7E-54
score: 181.6
IPR029039Flavoprotein-like domainSUPERFAMILY52218Flavoproteinscoord: 499..663
IPR004030Nitric oxide synthase, N-terminalPFAMPF02898NO_synthasecoord: 95..455
e-value: 4.1E-165
score: 549.1
IPR004030Nitric oxide synthase, N-terminalSUPERFAMILY56512Nitric oxide (NO) synthase oxygenase domaincoord: 45..456
IPR017927Ferredoxin reductase-type FAD-binding domainPROSITEPS51384FAD_FRcoord: 708..945
score: 12.154
IPR017938Riboflavin synthase-like beta-barrelSUPERFAMILY63380Riboflavin synthase domain-likecoord: 698..939

Blast
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BLAST of TCONS_00049205-protein vs. Swiss-Prot (Human)
Match: NOS1 (Nitric oxide synthase, brain OS=Homo sapiens GN=NOS1 PE=1 SV=2)

HSP 1 Score: 1043.11 bits (2696), Expect = 0.000e+0
Identity = 537/1122 (47.86%), Postives = 730/1122 (65.06%), Query Frame = 0 
Query:   47 LKNLLEGSTMTDTLHQKAVGTVPCDQKTCLGSIYMPSNDDVPPGEMRPKEEVKKHATVFLNEYYTSLKKQNSESHVQRLKQVISEIDQTSTYELDIKELEFGARLAWRNAPRCNGRIQWKKLTLFDCRHVETASDMFGCITRHIQYATNKGNLRSTITIFPHKKSAMSEYRVWNSQLVRYAGYRQKDGTVIGDPASVELTEVCKKLGWKGYGGHFDIIPMVLSAPGQPPELFEIPKDIVLEVPITHPHYPIDK-LGLKWYAIPAVANMMLDIGGLQFTACPFSGWYNATEIGARNFTDTCRYNLMKPAAELCGFDTSNMATLWKDKIAVELTVAVIHSFQKSGVTIVDHHSSAETFMKHIKDEEKLRGGCPTDWVWVVPPLTGGIMPMFHQEFLNYKLRPSYEYQPDPWKYLPNAKLQNENESEG-KGYPKRR----FKDVVKAVKFSSSMMSRAMEKRSKATILYATETGKSEKFANTLNEILLFAFDSKVVCMEDYDVSDLPHEQCVIIVTSTFGNGESPDNGRSFQDGLEAM-----IAETASS------------------------SLSTESLEILTNVRFAVFGLGSRAYPNFCSFAHIVKRLLKSLGGEEIHETGEGDELCGQESSFNEWAAGAFKAACDSFGIYD-VDMKAAISSIASSAKDWKKGLFRLSKTPVGNESIPEALSKLHRKKVVPAKCISVQNLQSSQSDRVTNLVKIDRCGHDEIMYKAGDHLSVYPTNEKVLVDALLDRVICDVGYDDCVTMEIKE--------VDKWVQSNKIPFVTTLRQMITSYLDITSPPSPKLLAVFSEEATNEEEKYELELLSTDNDKYEDWSHANYPNIVEVLEKFKSVACDVTMLINHLPLLNPRHYSISSSQDLHPSEVHVTVALVSYEIK---GNTHNGVCSYYLSNLKPNDVVYCNIRKASSFYLPTDRSSPVIMIGPGTGIAPFRSFWQQALFEHTENKDSVKRDMTLYFGCRNSKHDDIYAKETTELVNQKILSSVRTAYSREENLPKTYVQQILHQDM-EKVGETILDKQGHVYVCGDVTMASDVSKMITKILQEYAALSDEEAKQFISELRTSKRYHEDIFGVTLKVKEVTEKVRKGS 1120
            +KN      +TDTLH K+     C +  C+GSI  PS     P ++R K ++   A  F+++YY+S+K+  S++H++RL++V  EID TSTY+L   EL +GA+ AWRNA RC GRIQW KL +FD R   TA  MF  I  H++YATNKGNLRS ITIFP +     ++RVWNSQL+RYAGY+Q DG+ +GDPA+V+ TE+C + GWK   G FD++P++L A G  PELF+IP ++VLEVPI HP +   K LGLKWY +PAV+NM+L+IGGL+F+ACPFSGWY  TEIG R++ D  RYN+++  A+    D    ++LWKD+  VE+ +AV++SFQ   VTIVDHHS+ E+F+KH+++E + RGGCP DWVW+VPP++G I P+FHQE LNY+L PS+EYQPDPW         N +  +G  G P +R    FK + +AVKFS+ +M +AM KR KATILYATETGKS+ +A TL EI   AFD+KV+ ME+YD+  L HE  V++VTSTFGNG+ P+NG  F   L  M     + E   S                          + ES   L NVRF+VFGLGSRAYP+FC+F H V  LL+ LGGE I +  EGDELCGQE +F  WA   FKAACD F + D V+++ A +S+ S+ + WK+  FRL+      E + + LS +H+K+V  A+ +S QNLQS +S R T  V++   G  E+ Y+ GDHL V+P N + LV+AL++R+      +  V +E+ E        +  W    ++P  T   Q    YLDIT+PP+P  L  F+  AT+E+EK  L +LS    +YE+W     P IVEVLE+F S+    T+L+  L LL PR+YSISSS D++P EVH+TVA+VSY  +   G  H+GVCS +L+ ++ +++V C +R A SF+LP +   P I++GPGTGIAPFRSFWQQ  F+  ++K      M L FGCR SK D IY +ET +  N+ +   + TAYSRE + PK YVQ IL + + E V   + ++ GH+YVCGDVTMA+DV K I +I+ +   LS E+A  FIS +R   RYHEDIFGVTL+  EVT ++R  S
Sbjct:  308 VKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVRTKGQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPW---------NTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKVMSMEEYDIVHLEHETLVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDRSWKRNKFRLTFVAEAPE-LTQGLSNVHKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERNTALGVISNWTDELRLPPCTIF-QAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLSKGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYRTRDGEGPIHHGVCSSWLNRIQADELVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFD-IQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDKPKKYVQDILQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSAEDAGVFISRMRDDNRYHEDIFGVTLRTYEVTNRLRSES 1417
The following BLAST results are available for this feature:
BLAST of TCONS_00049205-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
NOS10.000e+047.86Nitric oxide synthase, brain OS=Homo sapiens GN=NO... [more]
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